This combination medication contains proton pump inhibitor and an antidopaminergic agent, prescribed for dyspepsia and gastro-esophageal reflux disease. Pantoprazole is indicated for the short-term treatment in the healing and symptomatic relief of erosive esophagitis. Also, Pantoprazole suppresses the final step in gastric acid production. Where, Domperidone is a very specific blocker of dopamine receptor. It speeds gastrointestinal peristalsis, cause prolactin release.